New Weapons to Fight against Staphylococcus aureus Skin Infections

The treatment of Staphylococcus aureus skin and soft tissue infections faces several challenges, such as the increased incidence antibiotic-resistant strains fact that antibiotics available to treat methicillin-resistant S. present low bioavailability, are not easily metabolized, cause severe secondary effects. Moreover, besides susceptibility pattern isolates detected in vitro, during patient treatment, may never encounter bacteria because hides within biofilms or inside eukaryotic cells. In addition, vascular compromise well other comorbidities impede proper arrival when antibiotic is given parenterally. this manuscript, we revise some more promising strategies improve sensitivity, delivery, including combination with bactericidal nanomaterials, chemical inhibitors, antisense oligonucleotides, lytic enzymes, among others. alternative non-antibiotic-based experimental therapies, delivery antimicrobial peptides, bioactive glass nanoparticles nanocrystalline cellulose, phototherapies, hyperthermia, also reviewed.